The pathogenesis and characterization of oral mucositis associated with cancer therapy

Abstract

Purpose/objectives: To describe the current knowledge about the pathogenesis of oral mucositis associated with cancer therapy and oral mucositis.

Data sources: Published research and literature review articles, books, and posters of findings that have been selected for presentation at research conferences.

Data synthesis: Aggressive cancer treatment yields gains in cure or sustained control but also in oral complications, including oral mucositis. Recent work suggests that oral mucositis involves a series of biologically and physiologically complex cellular and tissue interactions that vary in accordance with treatment type and characteristics.

Conclusions: The impact of treatment-related oral mucositis in patients is multifaceted and can significantly affect patients' experiences in terms of morbidity and treatment course. The creation of effective, targeted management strategies ultimately relies on a better understanding of the biologic processes underlying oral mucositis development coupled with systematic use of assessment tools.

Implications for nursing: Incorporating current knowledge about the pathogenesis of oral mucositis with regular use of available assessment instruments can help to ensure prompt recognition of oral manifestations and facilitate better treatment strategies.