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. 2003 Jan;1(1):21-8.
doi: 10.3121/cmr.1.1.21.

Genetics of prostate cancer

Kai Qi Zhang  1 , Sherry A Salzman, D J Reding, Brian K Suarez, William J Catalona, James K Burmester
Affiliations

Genetics of prostate cancer

Kai Qi Zhang et al. Clin Med Res. 2003 Jan.

Abstract

Prostate cancer is the most frequently diagnosed visceral cancer of men, responsible for approximately 40,000 deaths in adult males per year. To identify the genetic causes of prostate cancer, we performed a whole genome scan of affected sib pairs, using DNA markers spaced evenly across the human genome. We demonstrated that regions on chromosomes 1, 4, 5, 7, 8, 11, 16 and 19 might harbor genes that predispose individuals to prostate cancer and may affect tumor growth rate and tumor aggressiveness. Here we present DNA sequence analysis of KIAA 0872 and 17-beta hydroxysteroid dehydrogenase that are located on chromosome 16 within the mapped region, and we demonstrate that neither of these genes carries mutations in the protein coding region or their splice junction sites. These results suggest that these genes are less likely to be associated with the cause of familial prostate cancer.

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Figures

Figure 1
Figure 1
Northern analysis of 17β-HSD. Samples are:

  1. Total Human prostate

  2. LNCaP

  3. Du145

  4. PC-3

  5. PZ-HPV-7

  6. Ca-HPV-10

  7. PNT2

  8. Clonetics normal epithelial cells

Figure 2
Figure 2
Northern analysis of KIAA 0872 expression in prostate. Samples are the same as figure 1.
See this image and copyright information in PMC

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