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Review
. 2005 Jun;115(6):1419-24.
doi: 10.1172/JCI24757.

Mapping quantitative trait loci in humans: achievements and limitations

Partha P Majumder  1 , Saurabh Ghosh
Affiliations
Review

Mapping quantitative trait loci in humans: achievements and limitations

Partha P Majumder et al. J Clin Invest. 2005 Jun.

Abstract

Recent advances in statistical methods and genomic technologies have ushered in a new era in mapping clinically important quantitative traits. However, many refinements and novel statistical approaches are required to enable greater successes in this mapping. The possible impact of recent findings pertaining to the structure of the human genome on efforts to map quantitative traits is yet unclear.

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Figures

Figure 1
Figure 1
Genetic effects of a single QTL with 2 alleles. The variances of QT values within genotypes can be unequal. The differences in mean values between AA and Aa genotypes need not be the same as the difference in the mean values between Aa and aa genotypes. If the mean value of the QT for genotype Aa is exactly in the middle of the mean values for genotypes AA and aa, then the 2 alleles A and a have additive effects. If the heterozygote mean is shifted toward the mean value of either of the homozygotes, then there is a dominance effect.
See this image and copyright information in PMC

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