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Review
. 2005 Jun;115(6):1440-8.
doi: 10.1172/JCI24759.

Finding schizophrenia genes

George Kirov  1 , Michael C O'Donovan, Michael J Owen
Affiliations
Review

Finding schizophrenia genes

George Kirov et al. J Clin Invest. 2005 Jun.

Abstract

Genetic epidemiological studies suggest that individual variation in susceptibility to schizophrenia is largely genetic, reflecting alleles of moderate to small effect in multiple genes. Molecular genetic studies have identified a number of potential regions of linkage and 2 associated chromosomal abnormalities, and accumulating evidence favors several positional candidate genes. These findings are grounds for optimism that insight into genetic factors associated with schizophrenia will help further our understanding of this disease and contribute to the development of new ways to treat it.

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Figures

Figure 1
Figure 1
Risk of developing schizophrenia in relatives of schizophrenic probands. The data are based on the review of studies compiled by Gottesman (3).
Figure 2
Figure 2
Locations of linkage findings and genes discussed in this paper. Linkages that reached genome-wide significance on their own according to the criteria set forth by Lander and Kruglyak (33) or those that have received strong support from more than one sample are shown. The numbers in black are the numbers of the chromosomes. The numbers in red refer to the references.
Figure 3
Figure 3
Chromosome 22 and the location of the VCFS deletions. The positions of candidate genes within the typically deleted region that are discussed in this paper are also indicated. The frequencies of the deleted regions are taken from Shaikh et al. (103).
See this image and copyright information in PMC

References

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