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. 1979 Dec;64(6):1608-13.
doi: 10.1172/JCI109622.

Induction of suppressor activity in the autologous mixed lymphocyte reaction and in cultures with concanavalin A

J B Innes, M M Kuntz, Y T Kim, M E Weksler

Induction of suppressor activity in the autologous mixed lymphocyte reaction and in cultures with concanavalin A

J B Innes et al. J Clin Invest. 1979 Dec.

Abstract

T lymphocytes that are activated in the autologous mixed lymphocyte reaction (MLR) have suppressor activity. Concanavalin A (Con A) augments the suppressor activity generated in cultures containing both T and non-T lymphocytes and can induce suppressor activity in T-lymphocyte preparations that contain too few (10%) non-T cells to generate a significant autologous MLR. However, when such T-lymphocyte preparations are further depleted of adherent cells and contain less than 2% non-T cells, Con A fails to induce suppressor activity. These findings support the concept that an autologous MLR may play an important role in generation of suppressor cells by Con A.

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