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. 2005 May;36(3):341-3.

[The expression of TRAIL, TRAIL-R (DR4, DcR1) and Fas-L in patients with ovarian cancer]

[Article in Chinese]
Chun-mei Li  1 , Zhi-lan Peng, Kai-xuan Yang
Affiliations
  • PMID: 15931863

[The expression of TRAIL, TRAIL-R (DR4, DcR1) and Fas-L in patients with ovarian cancer]

[Article in Chinese]
Chun-mei Li et al. Sichuan Da Xue Xue Bao Yi Xue Ban. 2005 May.

Abstract

Objective: To investigate the apoptosis induced by TRAIL, TRAIL-R and Fas-L in patients

Methods: The expression of TRAIL, TRAIL-R (DR4,DcR1) and Fas-L in ovarian cancer was detected with immunohistochemistry.

Results: The levels of DR4 and DcR1 expression in ovarian carcinoma with ovarian carcinoma were lower than that of normal tissues. The positive rate of DR4 in well-differentiated ovarian carcinoma was significantly higher than that in poorly differentiated ovarian carcinoma (92.31% vs 54.55%, P < 0.05). The expression of TRAIL was significantly correlated with that of Fas-L (r = 0.777).

Conclusion: The expressions of DR4 and DcR1 are lower than that of normal tissues, and the expression of DR4 might be a prognostic factor in ovarian cancer.

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