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Meta-Analysis
. 2005 Jun 4;330(7503):1297.
doi: 10.1136/bmj.330.7503.1297.

Cost utility analysis of co-prescribed heroin compared with methadone maintenance treatment in heroin addicts in two randomised trials

Marcel G W Dijkgraaf  1 , Bart P van der Zanden, Corianne A J M de Borgie, Peter Blanken, Jan M van Ree, Wim van den Brink
Affiliations
Meta-Analysis

Cost utility analysis of co-prescribed heroin compared with methadone maintenance treatment in heroin addicts in two randomised trials

Marcel G W Dijkgraaf et al. BMJ. .

Abstract

Objective: To determine the cost utility of medical co-prescription of heroin compared with methadone maintenance treatment for chronic, treatment resistant heroin addicts.

Design: Cost utility analysis of two pooled open label randomised controlled trials.

Setting: Methadone maintenance programmes in six cities in the Netherlands.

Participants: 430 heroin addicts.

Interventions: Inhalable or injectable heroin prescribed over 12 months. Methadone (maximum 150 mg a day) plus heroin (maximum 1000 mg a day) compared with methadone alone (maximum 150 mg a day). Psychosocial treatment was offered throughout.

Main outcome measures: One year costs estimated from a societal perspective. Quality adjusted life years (QALYs) based on responses to the EuroQol EQ-5D at baseline and during the treatment period.

Results: Co-prescription of heroin was associated with 0.058 more QALYs per patient per year (95% confidence interval 0.016 to 0.099) and a mean saving of 12,793 euros (8793 pounds sterling, 16,122 dollars) (1083 to 25,229 euros) per patient per year. The higher programme costs (16 222 euros; lower 95% confidence limit 15,084 euros) were compensated for by lower costs of law enforcement (- 4129 euros; upper 95% confidence limit - 486 euros) and damage to victims of crime (- 25,374 euros; upper 95% confidence limit - 16,625 euros). The results were robust for the use of national EQ-5D tariffs and for the exclusion of the initial implementation costs of heroin treatment. Completion of treatment is essential; having participated in any abstinence treatment in the past is not.

Conclusions: Co-prescription of heroin is cost effective compared with treatment with methadone alone for chronic, treatment resistant heroin addicts.

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Figures

Figure 1
Figure 1
Cost effectiveness plane, showing differences between experimental treatment (methadone plus heroin) and control treatment (methadone alone) after 25 000 bootstrap replications. Vertical axis shows differences in mean total costs, horizontal axis shows differences in mean QALYs. The experimental treatment generated lower costs and more QALYs than the control treatment in 98% of all replications
See this image and copyright information in PMC

References

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