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Review
. 2005 Jul;17(4):397-9.
doi: 10.1097/01.cco.0000161746.32511.41.

Colorectal carcinomatosis: a new oncologic frontier

Paul H Sugarbaker  1
Affiliations
Review

Colorectal carcinomatosis: a new oncologic frontier

Paul H Sugarbaker. Curr Opin Oncol. 2005 Jul.

Abstract

Purpose of review: In the past, carcinomatosis from colorectal cancer was determined to be a lethal condition with a short survival.

Recent findings: A new treatment strategy starts with cytoreductive surgery in an attempt to remove all visible evidence of cancer implants. Then, chemotherapy is used in the operating room with moderate hyperthermia (41-43 degrees C) in an attempt to eradicate microscopic residual disease. Multiple phase II, a phase III, and a multi-institutional phase II study of 503 patients showed that approximately one-third of these patients can survive long term.

Summary: The expansion of treatment options, including cytoreductive surgery followed by chemotherapy with hyperthermia, to a larger number of patients is appropriate.

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