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Review
. 2005 Apr;5(4):443-9.
doi: 10.1517/14712598.5.4.443.

Cancer immunotherapy based on the killing of Salmonella typhimurium-infected tumour cells

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Review

Cancer immunotherapy based on the killing of Salmonella typhimurium-infected tumour cells

Daniel A Saltzman. Expert Opin Biol Ther. 2005 Apr.

Abstract

The use of bacteria for anticancer purposes was first attempted over 100 years ago. Recently, several strains of Salmonella have been shown to possess anticancer activity and, interestingly, Salmonella possesses a unique propensity to track to tumour tissue in vivo. This review presents the use of Salmonella for cancer immunotherapy, including the distinguishing characteristics of this organism and preclinical as well as clinical data.

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