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. 1992 Apr;19(4):524-8.

Cytokines and soluble interleukin 2 receptors in rheumatoid arthritis

R E Wolf  1 , W G Brelsford, V C Hall, S B Adams
Affiliations
  • PMID: 1593571

Cytokines and soluble interleukin 2 receptors in rheumatoid arthritis

R E Wolf et al. J Rheumatol. 1992 Apr.

Abstract

Cytokines (IL-1 alpha and IL-2) and soluble interleukin 2 receptors (sIL-2r) were evaluated in patients with rheumatoid arthritis (RA) and controls. In RA, serum sIL-2r and IL-1 alpha were increased, and sIL-2r were significantly higher in synovial fluid than in serum. Serum levels of sIL-1r but not IL-1 alpha were increased in patients with acute infections, suggesting additional discriminatory specificity for IL-1 alpha. Both tender and swollen joint scores were higher for patients with RA with serum sIL-2r levels greater than or equal to 700 U/ml. Quantitation of immune mediators may be useful in the clinical assessment of RA in addition to their implication regarding the pathogenesis of the disease.

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