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Review
. 2005 Jun 6;182(11):575-9.
doi: 10.5694/j.1326-5377.2005.tb06817.x.

Proteomics and disease: opportunities and challenges

Maria Kavallaris  1 , Glenn M Marshall
Affiliations
Review

Proteomics and disease: opportunities and challenges

Maria Kavallaris et al. Med J Aust. .

Abstract

Since the human genome was sequenced, there has been intense activity to understand the function of the 30,000 identified genes; attention has now turned to the products of genes--proteins. Proteomics is the large-scale study of the structure and function of proteins; it includes the rapidly evolving field of disease proteomics, which aims to identify proteins involved in human disease and to understand how their expression, structure and function cause illness. Proteomics has identified proteins that offer promise as diagnostic or prognostic markers, or as therapeutic targets in a range of illnesses, including cancer, immune rejection after transplantation, and infectious diseases such as tuberculosis and malaria; it has the potential to allow patient-tailored therapy. Some major challenges remain, both technical (eg, detecting "low-abundance" proteins, and maintaining sample stability) and in data management (eg, correlating changes in proteins with disease processes).

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References

    1. Fontanarosa PB, DeAngelis CD. Medical applications of biotechnology. JAMA 2005; 293: 866–867. - PubMed
    1. Petricoin E, Wulfkuhle J, Espina V, Liotta LA. Clinical proteomics: revolutionizing disease detection and patient tailoring therapy. J Proteome Res 2004; 3: 209–217. 15113096. - PubMed
    1. Ozols RF. Update on the management of ovarian cancer. Cancer J 2002; 8 Suppl 1: S22–S30. - PubMed
    1. Petricoin EF, Ardekani AM, Hitt BA, et al. Use of proteomic patterns in serum to identify ovarian cancer. Lancet 2002; 359: 572–577. 11867112. - PubMed
    1. Baggerly KA, Morris JS, Edmonson SR, Coombes KR. Signal in noise: evaluating reported reproducibility of serum proteomic tests for ovarian cancer. J Natl Cancer Inst 2005; 97: 307–309. 15713966. - PubMed

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