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. 2005 Jul;112(7):1186-91.
doi: 10.1016/j.ophtha.2005.03.006.

Determinants and heritability of intraocular pressure and cup-to-disc ratio in a defined older population

Ta C Chang  1 , Nathan G Congdon, Robert Wojciechowski, Beatriz Muñoz, Donna Gilbert, Ping Chen, David S Friedman, Sheila K West
Affiliations

Determinants and heritability of intraocular pressure and cup-to-disc ratio in a defined older population

Ta C Chang et al. Ophthalmology. 2005 Jul.

Abstract

Purpose: To investigate the heritability of intraocular pressure (IOP) and cup-to-disc ratio (CDR) in an older well-defined population.

Design: Family-based cohort study.

Participants: Through the population-based Salisbury Eye Evaluation study, we recruited 726 siblings (mean age, 74.7 years) in 284 sibships.

Methods: Intraocular pressure and CDR were measured bilaterally for all participants. The presence or absence of glaucoma was determined by a glaucoma specialist for all probands on the basis of visual field, optic nerve appearance, and history. The heritability of IOP was calculated as twice the residual between-sibling correlation of IOP using linear regression and generalized estimating equations after adjusting for age, gender, mean arterial pressure, race, self-reported diabetes status, and history of systemic steroid use. The heritability of CDR was calculated using the same model and adjustments as above, while also adjusting for IOP.

Main outcome measures: Heritability and determinants of IOP and CDR, and impact of siblings' glaucoma status on IOP and CDR.

Results: We estimated the heritability to be 0.29 (95% confidence interval [CI], 0.12-0.46) for IOP and 0.56 (95% CI, 0.35-0.76) for CDR in this population. Mean IOP in siblings of glaucomatous probands was statistically significantly higher than in siblings of normal probands (mean difference, 1.02 mmHg; P = 0.017). The mean CDR in siblings of glaucomatous probands was 0.07 (or 19%) larger than in siblings of glaucoma suspect referrals (P = 0.045) and siblings of normal probands (P = 0.004).

Conclusions: In this elderly population, we found CDR to be highly heritable and IOP to be moderately heritable. On average, siblings of glaucoma patients had higher IOPs and larger CDRs than siblings of nonglaucomatous probands.

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Conflict of interest statement

The authors declare that they have no financial interest in the devices and/or techniques discussed in the article.

References

    1. Quigley HA. Number of people with glaucoma worldwide. Br J Ophthalmol. 1996;80:389–93. - PMC - PubMed
    1. Eye Disease Prevalence Study Group. The prevalence of glaucoma among adults in the United States. Arch Ophthalmol. 2004;122:532–8. - PMC - PubMed
    1. Foster PJ, Buhrmann R, Quigley HA, Johnson GJ. The definition and classification of glaucoma in prevalence surveys. Br J Ophthalmol. 2002;86:238–42. - PMC - PubMed
    1. Wolfs RC, Klaver CC, Ramrattan RS, et al. Genetic risk of primary open-angle glaucoma: population-based familial aggregation study. Arch Ophthalmol. 1998;116:1640–5. - PubMed
    1. Duke-Elder S. Text-book of Ophthalmology. Vol. 3. St. Louis: CV Mosby; 1945. Diseases of the Inner Eye.

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