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. 2005 May;34(3):260-2.
doi: 10.3785/j.issn.1008-9292.2005.03.014.

[Determination of interleukine-16 levels in peritoneal fluid and serum of women with endometriosis]

[Article in Chinese]
Jun Lin  1 , Xin-mei Zhang, Lin Deng, Zheng-yun Chen, Li Chen
Affiliations

[Determination of interleukine-16 levels in peritoneal fluid and serum of women with endometriosis]

[Article in Chinese]
Jun Lin et al. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2005 May.

Abstract

Objective: To investigate the role of interleukine-16 (IL-16) in the pathogenesis of endometriosis.

Methods: Enzyme-linked immunosorbent assay (ELISA) was used to determine the levels of IL-16 in peritoneal fluid and serum specimens of 22 women with different stage endometriosis and 22 controls.

Results: The median levels of IL-16 in peritoneal fluid and serum were 290.5 pg/ml and 539.4 pg/ml in women with endometriosis, and 296.6 pg/ml and 778.1 pg/ml in controls, respectively; there was no significant difference between two groups (P>0.05). However, the IL-16 levels in peritoneal fluid and serum of patients with minimal/mild stage endometriosis and controls were all significantly higher than those of patients with moderate/severe endometriosis (P<0.01, <0.05). In addition, there was no statistical correlation of peritoneal IL-16 levels with those in serum (P>0.05).

Conclusion: Reduced levels of IL-16 in peritoneal fluid and serum of women with advanced stage endometriosis may imply a role of IL-16 in the development and progression of endometriosis.

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