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. 2005 Jun 15;127(23):8254-5.
doi: 10.1021/ja0515295.

A potent transactivation domain mimic with activity in living cells

Bo Liu  1 , Prasanna G Alluri, Peng Yu, Thomas Kodadek
Affiliations

A potent transactivation domain mimic with activity in living cells

Bo Liu et al. J Am Chem Soc. .

Abstract

Transcriptional coactivator-binding peptoids were isolated from a large combinatorial library. One of these molecules is shown to function as a potent activation domain surrogate in mammalian cells. Up to a 900-fold increase in expression of a Gal4-responsive reporter gene is observed when a steroid conjugate of the peptoid is incubated with HeLa cells expressing a Gal4 DNA-binding domain (DBD)-glucocorticoid receptor ligand-binding domain (GRLBD) fusion protein.

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