Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2006 Jan;65(1):7-13.
doi: 10.1136/ard.2005.036269. Epub 2005 Jun 7.

Problem of the atherothrombotic potential of non-steroidal anti-inflammatory drugs

W W Bolten  1
Affiliations
Review

Problem of the atherothrombotic potential of non-steroidal anti-inflammatory drugs

W W Bolten. Ann Rheum Dis. 2006 Jan.

Abstract

Treatment of pain in rheumatoid arthritis must take into account the gastrointestinal and cardiovascular risk of individual patients. Adequate results are not yet available, and until they are, treatment recommendations must take into account, not only the more favourable gastrointestinal risk profile of selective COX-2 inhibitors, but also the potential atherothrombotic risk of any NSAID or selective COX-2 inhibitor treatment.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Ross R. Atherosclerosis—an inflammatory disease. N Engl J Med 1999340115–126. - PubMed
    1. FitzGerald G A. Cardiovascular pharmacology of nonselective nonsteroidal anti‐inflammatory drugs and coxibs: clinical considerations. Am J Cardiol 20028926–32D. - PubMed
    1. Chenevard R, Hurlimann D, Bechir M, Enseleit F, Spieker L, Hermann M.et al Selective COX‐2 inhibition improves endothelial function in coronary artery disease. Circulation 2003107405–409. - PubMed
    1. Egan K M, Lawson J A, Fries S, Koller B, Rader D J, Smyth E M.et al COX‐2‐derived prostacyclin confers atheroprotection on female mice. Science 20043061954–1957. - PubMed
    1. Cheng Y, Austin S C, Rocca B, Koller B H, Coffman T M, Grosser T.et al Role of prostacyclin in the cardiovascular response to thromboxane A2. Science 2002296539–541. - PubMed

MeSH terms

Substances