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. 2005 Jul 1;192(1):166-9.
doi: 10.1086/430615. Epub 2005 May 25.

Antibody avidity maturation during severe acute respiratory syndrome-associated coronavirus infection

Paul K S Chan  1 , Pak-Leong Lim, Esther Y M Liu, Jo L K Cheung, Danny T M Leung, Joseph J Y Sung
Affiliations

Antibody avidity maturation during severe acute respiratory syndrome-associated coronavirus infection

Paul K S Chan et al. J Infect Dis. .

Abstract

The maturation of virus-specific immunoglobulin G avidity during severe acute respiratory syndrome-associated coronavirus infection was examined. The avidity indices were low (mean +/- SD, 30.8% +/- 11.6%) among serum samples collected < or =50 days after fever onset, intermediate (mean +/- SD, 52.1% +/- 14.1%) among samples collected between days 51 and 90, and high (mean +/- SD, 78.1% +/- 8.0%) among samples collected after day 90. Avidity indices of 40% and 55% could be considered as cutoff values for determination of recent (< or =50 days) and past (>65 days) infection, respectively. Measurement of antibody avidity can be used to differentiate primary infection from reexposure and to assess humoral responses to candidate vaccines.

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Figures

Figure 1
Figure 1
Severe acute respiratory syndrome–associated coronavirus–specific IgG antibody avidity in relation to time after fever onset
Figure 2
Figure 2
Changes in severe acute respiratory syndrome–associated coronavirus–specific IgG antibody avidity in paired serum samples
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References

    1. World Health Organization Summary of probable SARS cases with onset of illness from 1 November 2002 to 31 July 2003. Available at: http://www.who.int/csr/sars/country/table2003_09_23/en/print.html. Accessed 30 December 2003.
    1. Lim PL, Kurup A, Gopalakrishna G, et al. Laboratory‐acquired severe acute respiratory syndrome. N Engl J Med. 2004;350:1740–5. - PubMed
    1. World Health Organization Severe acute respiratory syndrome (SARS) in Taiwan, China. Available at: http://www.who.int/csr/don/2003_12_17/en/. Accessed 5 August 2004.
    1. World Health Organization Update 4: review of probable and laboratory‐confirmed SARS cases in southern China. Available at: http://www.who.int/csr/don/2004_01_27/en/. Accessed 5 August 2004.
    1. World Health Organization Investigation into China’s recent SARS outbreak yields important lessons for global public health. Available at: http://www.wpro.who.int/sars/docs/update/update_07022004.asp. Accessed 5 August 2004.

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