Review
doi: 10.1016/j.legalmed.2004.12.003.
Molecular mechanisms of Lewis antigen expression
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- PMID: 15946883
- DOI: 10.1016/j.legalmed.2004.12.003
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Review
Molecular mechanisms of Lewis antigen expression
Leg Med (Tokyo).
2005 Jul.
Abstract
Lewis antigens comprise type 1 (Lewis a, Lewis b) and type 2 (Lewis X, Lewis Y) carbohydrates. Lewis X and Lewis Y are regarded as tumor-associated markers, and some of these antigens and their derivatives interact with selectins, mediating cell-to-cell adhesion. In addition, Lewis b on the gastric epithelial surface has been identified as an acceptor for attachment of Helicobacter pylori. In this review, we describe the regulation the expression of type 1 Lewis antigens on erythrocytes or digestive organs by two genes (FUT2 and FUT3), and the ethnic specificity of the polymorphism of these genes for forensic use.
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