Recombination at collapsed replication forks: the payoff for survival
- PMID: 15949436
- DOI: 10.1016/j.molcel.2005.05.018
Recombination at collapsed replication forks: the payoff for survival
Abstract
Recombination is believed to assist replication when forks collapse. By using an elegant system, Lambert et al. (2005) address the consequences of recombination at blocked forks. They show that chromosomal rearrangements are the price to pay for cell viability when forks collapse.
Comment on
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Gross chromosomal rearrangements and elevated recombination at an inducible site-specific replication fork barrier.Cell. 2005 Jun 3;121(5):689-702. doi: 10.1016/j.cell.2005.03.022. Cell. 2005. PMID: 15935756
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