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Review
. 2005 Jun 10;18(6):617-22.
doi: 10.1016/j.molcel.2005.05.008.

Chromatin in need of a fix: phosphorylation of H2AX connects chromatin to DNA repair

Christophe Thiriet  1 , Jeffrey J Hayes
Affiliations
Free article
Review

Chromatin in need of a fix: phosphorylation of H2AX connects chromatin to DNA repair

Christophe Thiriet et al. Mol Cell. .
Free article

Abstract

A bevy of recent reports have firmly established a mechanistic link between a histone posttranslational modification associated with DNA double-strand breaks and recruitment of chromatin-modifying activities. These papers show that in addition to providing signals for transcriptional regulation, specific histone "codes" can coordinate and target multiple activities involved in DNA repair.

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