doi: 10.1016/j.apradiso.2005.03.005.
Module-assisted synthesis of the bifunctional labelling agent N-succinimidyl 4-[(18)F]fluorobenzoate ([(18)F]SFB)
Affiliations
- PMID: 15949940
- DOI: 10.1016/j.apradiso.2005.03.005
Item in Clipboard
Module-assisted synthesis of the bifunctional labelling agent N-succinimidyl 4-[(18)F]fluorobenzoate ([(18)F]SFB)
Appl Radiat Isot.
2005 Sep.
Abstract
The three-step radiosynthesis of N-succinimidyl 4-[(18)F]fluorobenzoate ([(18)F]SFB) was adapted to a remotely controlled synthesis module. After optimization of the reaction conditions, the final [(18)F]SFB was obtained in decay-corrected radiochemical yields of 34-38% (related to [(18)F]fluoride; n=12) within a synthesis time of 68 min. The radiochemical purity was in the range of 93-96%.
Similar articles
-
Synthesis of N-succinimidyl 4-[18F]fluorobenzoate, an agent for labeling proteins and peptides with 18F.Nat Protoc. 2006;1(4):1655-61. doi: 10.1038/nprot.2006.264. Nat Protoc. 2006. PMID: 17487148
-
Fully automated preparation of n.c.a. 4-[18F]fluorobenzoic acid and N-succinimidyl 4-[18F]fluorobenzoate using a Siemens/CTI chemistry process control unit (CPCU).Appl Radiat Isot. 2007 Feb;65(2):199-203. doi: 10.1016/j.apradiso.2006.06.007. Epub 2006 Aug 28. Appl Radiat Isot. 2007. PMID: 16935516
-
Systematic comparison of two novel, thiol-reactive prosthetic groups for 18F labeling of peptides and proteins with the acylation agent succinimidyl-4-[18F]fluorobenzoate ([18F]SFB).Amino Acids. 2009 Feb;36(2):283-95. doi: 10.1007/s00726-008-0065-2. Epub 2008 Apr 15. Amino Acids. 2009. PMID: 18414978
-
Radiochemical synthesis of 2'-[18F]-labelled and 3'-[18F]-labelled nucleosides for positron emission tomography imaging.J Labelled Comp Radiopharm. 2014 May 15;57(5):333-7. doi: 10.1002/jlcr.3197. Epub 2014 Apr 1. J Labelled Comp Radiopharm. 2014. PMID: 24692121 Review.
-
Methods for (11) C- and (18) F-labelling of amino acids and derivatives for positron emission tomography imaging.J Labelled Comp Radiopharm. 2013 Mar-Apr;56(3-4):225-36. doi: 10.1002/jlcr.2996. J Labelled Comp Radiopharm. 2013. PMID: 24285329 Review.
Cited by
-
Development of a new thiol site-specific prosthetic group and its conjugation with [Cys(40)]-exendin-4 for in vivo targeting of insulinomas.Bioconjug Chem. 2013 Jul 17;24(7):1191-200. doi: 10.1021/bc400084u. Epub 2013 Jun 28. Bioconjug Chem. 2013. PMID: 23750453 Free PMC article.
-
Synthesis and pre-clinical evaluation of an (18)F-labeled single-chain antibody fragment for PET imaging of epithelial ovarian cancer.Am J Nucl Med Mol Imaging. 2016 Jul 6;6(3):185-98. eCollection 2016. Am J Nucl Med Mol Imaging. 2016. PMID: 27508105 Free PMC article.
-
Hypervalent aryliodine compounds as precursors for radiofluorination.J Labelled Comp Radiopharm. 2018 Mar;61(3):196-227. doi: 10.1002/jlcr.3570. Epub 2018 Feb 5. J Labelled Comp Radiopharm. 2018. PMID: 28981159 Free PMC article. Review.
-
Continuous-Flow Synthesis of N-Succinimidyl 4-[18F]fluorobenzoate Using a Single Microfluidic Chip.PLoS One. 2016 Jul 13;11(7):e0159303. doi: 10.1371/journal.pone.0159303. eCollection 2016. PLoS One. 2016. PMID: 27410684 Free PMC article.
-
Characterization of the Biodistribution and Systemic Absorption of TT-173, a New Hemostatic Agent of Recombinant Human Tissue Factor, Using Radiolabeling with 18F.Eur J Drug Metab Pharmacokinet. 2017 Aug;42(4):583-592. doi: 10.1007/s13318-016-0366-x. Eur J Drug Metab Pharmacokinet. 2017. PMID: 27550654
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
