doi: 10.1016/j.molbrainres.2005.02.029.
Epub 2005 Apr 2.
Expression of BLT1 leukotriene B4 receptor on the dorsal root ganglion neurons in mice
Affiliations
- PMID: 15950785
- DOI: 10.1016/j.molbrainres.2005.02.029
Item in Clipboard
Expression of BLT1 leukotriene B4 receptor on the dorsal root ganglion neurons in mice
Brain Res Mol Brain Res.
.
Abstract
We investigated using mice whether dorsal root ganglion (DRG) neurons express leukotriene B4 receptors. BLT1, but not BLT2, receptor mRNA was expressed in the DRG. Leukotriene B4 increased intracellular Ca2+ concentration in cultured DRG neurons, which was inhibited by leukotriene B4 antagonist. Many BLT1-immunoreactive neurons were small in size and positive for TRPV1. BLT1-immunoreactive fibers are present in the skin. The results suggest the expression of functional BLT1 receptors in the sensory neurons.
Similar articles
-
The leukotriene B4 receptors BLT1 and BLT2 form an antagonistic sensitizing system in peripheral sensory neurons.J Biol Chem. 2017 Apr 14;292(15):6123-6134. doi: 10.1074/jbc.M116.769125. Epub 2017 Feb 27. J Biol Chem. 2017. PMID: 28242764 Free PMC article.
-
Leukotriene B4 receptors BLT1 and BLT2: expression and function in human and murine mast cells.J Immunol. 2006 Sep 1;177(5):3439-47. doi: 10.4049/jimmunol.177.5.3439. J Immunol. 2006. PMID: 16920986
-
Differential induction of BLT receptor expression on human endothelial cells by lipopolysaccharide, cytokines, and leukotriene B4.Proc Natl Acad Sci U S A. 2006 May 2;103(18):6913-8. doi: 10.1073/pnas.0602208103. Epub 2006 Apr 19. Proc Natl Acad Sci U S A. 2006. PMID: 16624877 Free PMC article.
-
Therapeutic target of leukotriene B4 receptors, BLT1 and BLT2: Insights from basic research.Biochimie. 2023 Dec;215:60-68. doi: 10.1016/j.biochi.2023.06.014. Epub 2023 Jul 7. Biochimie. 2023. PMID: 37423557 Review.
-
Leukotriene B4 receptors.Prostaglandins Other Lipid Mediat. 2002 Aug;68-69:575-85. doi: 10.1016/s0090-6980(02)00056-4. Prostaglandins Other Lipid Mediat. 2002. PMID: 12432944 Review.
Cited by
-
Nociceptor Sensory Neuron-Immune Interactions in Pain and Inflammation.Trends Immunol. 2017 Jan;38(1):5-19. doi: 10.1016/j.it.2016.10.001. Epub 2016 Oct 25. Trends Immunol. 2017. PMID: 27793571 Free PMC article. Review.
-
Connections between Immune-Derived Mediators and Sensory Nerves for Itch Sensation.Int J Mol Sci. 2021 Nov 16;22(22):12365. doi: 10.3390/ijms222212365. Int J Mol Sci. 2021. PMID: 34830245 Free PMC article. Review.
-
Systemic leukotriene B4 receptor antagonism lowers arterial blood pressure and improves autonomic function in the spontaneously hypertensive rat.J Physiol. 2016 Oct 15;594(20):5975-5989. doi: 10.1113/JP272065. Epub 2016 Jul 8. J Physiol. 2016. PMID: 27230966 Free PMC article.
-
TRPV1 and SP: key elements for sepsis outcome?Br J Pharmacol. 2013 Dec;170(7):1279-92. doi: 10.1111/bph.12056. Br J Pharmacol. 2013. PMID: 23145480 Free PMC article. Review.
-
The absence of the leukotriene B4 receptor BLT1 attenuates peripheral inflammation and spinal nociceptive processing following intraplantar formalin injury.Mol Pain. 2015 Mar 12;11:11. doi: 10.1186/s12990-015-0010-9. Mol Pain. 2015. PMID: 25889478 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous
