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. 2005 Jun;7(6):499-500.
doi: 10.1016/j.ccr.2005.05.019.

Coevolution of cancer and stromal cellular responses

Laurie E Littlepage  1 , Mikala Egeblad, Zena Werb
Affiliations
Free article

Coevolution of cancer and stromal cellular responses

Laurie E Littlepage et al. Cancer Cell. 2005 Jun.
Free article

Abstract

It is now becoming apparent that multiple types of stromal cells, including macrophages, mast cells, adipocytes, and fibroblasts make pivotal contributions to carcinogenesis. In the May 6 issue of Cell, Orimo and colleagues (Orimo et al., 2005) show that carcinoma-associated fibroblasts can promote epithelial tumorigenesis by secreting the chemokine SDF-1alpha (CXCL12). SDF-1alpha stimulates carcinoma cell proliferation and recruitment of endothelial precursor cells.

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