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. 2005 Jun;129(6):791-4.
doi: 10.1111/j.1365-2141.2005.05516.x.

SHP1 expression in bone marrow biopsies of myelodysplastic syndrome patients: a new prognostic factor

Armando V Mena-Duran  1 , Summanuna H Togo, Lyudmila Bazhenova, Jose Cervera, Kelly Bethel, Maria L Senent, Jorge Nieva, Guillermo F Sanz, Miguel A Sanz, Alan Saven, Tomas Mustelin
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SHP1 expression in bone marrow biopsies of myelodysplastic syndrome patients: a new prognostic factor

Armando V Mena-Duran et al. Br J Haematol. 2005 Jun.

Abstract

Myelodysplastic syndrome (MDS) progresses into acute leukaemia with a variable time course. We analysed 45 newly diagnosed patients and found that the expression of the Src homology 2 domain-containing tyrosine phosphatase 1 (SHP1) had a significant impact on disease severity, progression and overall prognosis. Global or lineage-specific loss of SHP1 was observed by immunohistochemistry in bone marrow biopsies of MDS patients who progressed rapidly (P = 0.0021) and had shorter survival (P < 0.001). Cox regression analysis demonstrated that SHP1 expression in megakaryocytes had prognostic relevance for time to progression (P = 0.009) and overall survival (P = 0.001).

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