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Review
. 2005 May-Jun:67 Suppl 1:S26-8.
doi: 10.1097/01.psy.0000163456.22154.d2.

Hypercortisolemia and depression

Charles F Gillespie  1 , Charles B Nemeroff
Affiliations
Review

Hypercortisolemia and depression

Charles F Gillespie et al. Psychosom Med. 2005 May-Jun.

Abstract

Hypercortisolemia and dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis are often found in severe forms of depression. The authors review the history of techniques used to assess the functions of the HPA axis, evidence for hypercortisolemia as a state rather than trait component of depression, and treatment implications.

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