Metabolic investigation in psychiatric disorders

Abstract

A multiplicity of theories have been proposed over the years that aim to conceptualize the pathophysiology of neuropsychiatric disorders, including impaired neurotransmission, viral infections, genetic mutation, energy metabolism deficiency, excitotoxicity, oxidative stress, and others. It is likely that complex disorders such as schizophrenia, bipolar disorder, and major depression are associated with multiple etiologies and pathogenetic mechanisms. In light of the interwoven biochemistry of human organs, identifying a network of multiple interacting biochemical pathways that account for the constellation of clinical and biological features would advance our understanding of these disorders. One such approach is to evaluate simultaneously the multiple metabolites in order to uncover the dynamic relations in the relevant biochemical systems. These metabolites are a group of low-molecular-weight, redox-active compounds, such as antioxidants, amino acids, catecholamines vitamins, lipids, and nucleotides, which reflect the metabolic processes, including anabolism and catabolism as well as other related cellular processes (e.g., signal transduction, regulation, detoxification, etc.). Such an analytic approach has the potential to yield valuable insights into the likely complex pathophysiological mechanisms that affect multiple metabolic pathways and thereby offer multiple windows of therapeutic opportunities.