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Comparative Study
. 2005 Jun;20(3):402-8.
doi: 10.3346/jkms.2005.20.3.402.

Lung cancer screening with low-dose helical CT in Korea: experiences at the Samsung Medical Center

Semin Chong  1 , Kyung Soo Lee, Myung Jin Chung, Tae Sung Kim, Hojoong Kim, O Jung Kwon, Yoon-Ho Choi, Chong H Rhee
Affiliations
Comparative Study

Lung cancer screening with low-dose helical CT in Korea: experiences at the Samsung Medical Center

Semin Chong et al. J Korean Med Sci. 2005 Jun.

Abstract

To determine overall detection rates of lung cancer by low-dose CT (LDCT) screening and to compare histopathologic and imaging differences of detected cancers between high- and low-risk groups, this study included 6,406 asymptomatic Korean adults with >or=45 yr of age who underwent LDCT for lung cancer screening. All were classified into high- (>or=20 pack-year smoking; 3,353) and low-risk (3,053; <20 pack-yr smoking and non-smokers) groups. We compared CT findings of detected cancers and detection rates between high- and low-risk. At initial CT, 35% (2,255 of 6,406) had at least one or more non-calcified nodule. Lung cancer detection rates were 0.36% (23 of 6,406). Twenty-one non-small cell lung cancers appeared as solid (n=14) or ground-glass opacity (GGO) (n=7) nodules. Cancer likelihood was higher in GGO nodules than in solid nodules (p<0.01). Fifteen of 23 cancers occurred in high-risk group and 8 in low-risk group (p=0.215). Therefore, LDCT screening help detect early stage of lung cancer in asymptomatic Korean population with detection rate of 0.36% on a population basis and may be useful for discovering early lung cancer in low-risk group as well as in high-risk group.

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Figures

Fig. 1
Fig. 1
A 48-yr-old man with adenocarcinoma. (A) Lung window of initial screening low-dose CT scan obtained at level of right upper lobar bronchus shows 10-mm-sized ground-glass opacity nodule (arrow) in right upper lobe. (B) Lung window of thin-section (2.5-mm thickness) CT scan obtained at similar level to A shows clearly ground-glass opacity nature of nodule (arrow). Right upper lobectomy disclosed adenocarcinoma.
Fig. 2
Fig. 2
A 65-yr-old man with squamous cell carcinoma. (A) Lung window of initial screening low-dose CT (5-mm collimation) scan obtained at level of bronchus intermedius shows 5-mm-sized nodule (arrow) in bottom of anterior segment of right upper lobe. (B) Repeat CT scan obtained at same level to and 6 months after A shows interval increase in nodule size (arrow). Right upper lobectomy disclosed squamous cell carcinoma.
See this image and copyright information in PMC

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