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Comparative Study
. 2005 Jun;20(3):483-8.
doi: 10.3346/jkms.2005.20.3.483.

Development of Korean standard brain templates

Jae Sung Lee  1 , Dong Soo Lee, Jinsu Kim, Yu Kyeong Kim, Eunjoo Kang, Hyejin Kang, Keon Wook Kang, Jong Min Lee, Jae-Jin Kim, Hae Jeong Park, Jun Soo Kwon, Sun I Kim, Tae Woo Yoo, Kee Hyun Chang, Myung Chul Lee
Affiliations
Comparative Study

Development of Korean standard brain templates

Jae Sung Lee et al. J Korean Med Sci. 2005 Jun.

Abstract

We developed age, gender and ethnic specific brain templates based on MR and Positron-Emission Tomography (PET) images of Korean normal volunteers. Seventy-eight normal right-handed volunteers (M/F=49/29) underwent 3D T1-weighted SPGR MR and F-18-FDG PET scans. For the generation of standard templates, an optimal target brain that has the average global hemispheric shape was selected for each gender. MR images were then spatially normalized by linear transformation to the target brains, and normalization parameters were reapplied to PET images. Subjects were subdivided into 2 groups for each gender: the young/midlife (<55 yr) and the elderly groups. Young and elderly MRI/PET templates were composed by averaging the spatially normalized images. Korean templates showed different shapes and sizes (mean length, width, and height of the brains were 16.5, 14.3 and 12.1 cm for man, and 15.6, 13.5 and 11.4 cm for woman) from the template based on Caucasian (18.3, 14.2, and 13.3 cm). MRI and PET templates developed in this study will provide the framework for more accurate stereotactic standardization and anatomical localization.

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Figures

Fig. 1
Fig. 1
Flowchart for the strategy used in this study to select optimal target brains. Two different methods were independently used to determine 10 male and 10 female candidates, and those who were commonly selected by both methods were considered as a final candidate. The final target brain for each gender was selected with the consensus of 3 image specialists by considering the age of the subject, asymmetry of brain and size of the ventricles.
Fig. 2
Fig. 2
T1-SPGR MRI templates. (A) Young/midlife man. (B) Elderly man. (C) Young/midlife woman. (D) Elderly woman.
Fig. 3
Fig. 3
F-18-FDG PET templates. (A) Young/midlife man. (B) Elderly man. (C) Young/midlife woman. (D) Elderly woman.
See this image and copyright information in PMC

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