doi: 10.1016/j.exppara.2005.02.023.
Epub 2005 Apr 7.
Molecular characterization of Entamoeba histolytica RNase III and AGO2, two RNA interference hallmark proteins
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- PMID: 15955322
- DOI: 10.1016/j.exppara.2005.02.023
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Molecular characterization of Entamoeba histolytica RNase III and AGO2, two RNA interference hallmark proteins
Exp Parasitol.
2005 Jul.
Abstract
Entamoeba histolytica, a protozoan parasite with variable DNA content and complex ploidity, has defied most efforts aimed at gene depletion using classical genetic methods. In this study, we identified and characterized two proteins involved in the RNA interference (RNAi) pathway, RNase III and AGO2. Our results strengthen the findings that an RNAi pathway does exist in this parasite.
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