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Review
. 2005 Aug;28(8):397-400.
doi: 10.1016/j.tins.2005.05.008.

Retinoic acid induction of ES-cell-derived neurons: the radial glia connection

Tamara Glaser  1 , Oliver Brüstle
Affiliations
Review

Retinoic acid induction of ES-cell-derived neurons: the radial glia connection

Tamara Glaser et al. Trends Neurosci. 2005 Aug.

Abstract

Neuronal induction by retinoic acid (RA) is commonly used in embryonic stem (ES) cell differentiation. Two recent papers show that this paradigm induces a population of neurogenic precursors with properties of radial glia. Upon differentiation, RA-treated cells give rise to a defined and developmentally restricted neuronal lineage. This role of RA in cell fate specification provides new perspectives for studying the radial glia-neuron transition and for generating homogenous populations of neurons from ES cells.

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