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Review
. 2005 Aug;5(4):350-6.
doi: 10.1016/j.coph.2005.04.007.

Recent progress in targeting the Raf/MEK/ERK pathway with inhibitors in cancer drug discovery

Neil Thompson  1 , John Lyons
Affiliations
Review

Recent progress in targeting the Raf/MEK/ERK pathway with inhibitors in cancer drug discovery

Neil Thompson et al. Curr Opin Pharmacol. 2005 Aug.

Abstract

Since the discovery that activating mutations of the Ras GTPase were associated with 30% or more of human cancers, the RAF/MEK/ERK pathway has been the focus of intense drug discovery effort. Within the new class of molecularly targeted anti-cancer agents progressing through the late stages of clinical development, BAY 43-9006 and PD0325901 have shown considerable promise.

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