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. 2005 Jun 23;7(13):2731-4.
doi: 10.1021/ol050901i.

Sporolides A and B: structurally unprecedented halogenated macrolides from the marine actinomycete Salinispora tropica

Greg O Buchanan  1 , Philip G Williams, Robert H Feling, Christopher A Kauffman, Paul R Jensen, William Fenical
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Sporolides A and B: structurally unprecedented halogenated macrolides from the marine actinomycete Salinispora tropica

Greg O Buchanan et al. Org Lett. .

Abstract

[structure: see text] Analysis of the fermentation broth of a strain of the marine actinomycete Salinispora tropica has led to the isolation of two unprecedented macrolides, sporolides A (1) and B (2). The structures and absolute stereochemistries of both metabolites were elucidated using a combination of NMR spectroscopy and X-ray crystallography.

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