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. 2005 Jun 15;3(1):34.
doi: 10.1186/1477-7819-3-34.

Long term remission of metastatic placental site trophoblastic tumor (PSTT): Case report and review of literature

Nadereh Behtash  1 , Fatemeh Ghaemmaghami, Malihe Hasanzadeh
Affiliations

Long term remission of metastatic placental site trophoblastic tumor (PSTT): Case report and review of literature

Nadereh Behtash et al. World J Surg Oncol. .

Abstract

BACKGROUND: Placental site trophoblastic tumor (PSTT) is a rare and unique form of gestational trophoblastic disease (GTD). This tumor represents a neoplastic transformation of intermediate trophoblastic cells. We document a case of long term remission in a patient with metastatic PSTT. CASE PRESENTAION: A 27-year-old patient with metastatic PSTT was treated with combination therapy (chemotherapy and surgery). Patient is alive after 10 years without any evidence of recurrence. Literature on PSTT was searched using Medline and cross references, and pertinent articles were reviewed. CONCLUSION: With surgery and chemotherapy it is possible to achieve long-term remission in metastatic PSTT. Only a handful of previously reported cases with prolonged remission had been treated with the described combined chemotherapy and surgical approach. We suggest that this approach may be recommended for metastatic PSTT.

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Figures

Figure 1
Figure 1
Chest X-ray and Computerized tomographic scan showing multiple metastatic nodules in the lung
Figure 2
Figure 2
Photomicrograph showing proliferating intermediate trophoblast with scares cytotophoblastic and systrophoblastic elements
See this image and copyright information in PMC

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