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Case Reports
. 2005 Jul;64(7):1087-8.
doi: 10.1136/ard.2004.027128.

Successful treatment of refractory anterior scleritis in primary Sjogren's syndrome with rituximab

K Ahmadi-Simab, P Lamprecht, B Nölle, M Ai, W L Gross
Case Reports

Successful treatment of refractory anterior scleritis in primary Sjogren's syndrome with rituximab

K Ahmadi-Simab et al. Ann Rheum Dis. 2005 Jul.
No abstract available

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Figures

Figure 1
Figure 1
(A) Anterior scleritis and flow cytometric analysis of B cell population in primary Sjögren's syndrome before treatment with the monoclonal anti-CD20 antibody rituximab. (B) Induction of remission with rituximab. For flow cytometric analysis peripheral blood mononuclear cells were stained with fluorochrome conjugated monoclonal antibodies for cell surface antigens or appropriate negative (isotype) controls. Four colour flow cytometric analysis was performed using a FACSCalibur flow cytometer (Becton Dickinson) and CELL-Quest software (Becton Dickinson). Lymphocytes were gated for analysis based on light scattering properties. A second gate was set based on light scattering properties and CD45 perCP staining properties. Positively and negatively stained populations were calculated by quadrant dot plot analysis determined by isotype controls. Quadrant markers were positioned to include >99% of control (isotype) immunoglobulin stained cells in the lower left quadrant. The numbers given in the upper right quadrant of the FACS refer to the fraction of cells detected in each quadrant. B cells display CD19 expression. Before treatment about 10% of the circulating CD19+ B cell population belong to the CD5+ (B1) B cell fraction. After successful treatment with rituximab no circulating CD19+ B cells can be detected.
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