Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2006 Apr;21(3):201-8.
doi: 10.1007/s00384-005-0776-8. Epub 2005 Jun 16.

The insulin-like growth factor system and colorectal cancer: clinical and experimental evidence

M Davies  1 , S Gupta, G Goldspink, M Winslet
Affiliations
Review

The insulin-like growth factor system and colorectal cancer: clinical and experimental evidence

M Davies et al. Int J Colorectal Dis. 2006 Apr.

Abstract

Objective: The aim of this review is to clarify the involvement of the insulin-like growth factor (IGF) system in the development of colorectal malignancy.

Materials and methods: Medline searches were used to identify key articles relating the IGF system with the development of colorectal cancer.

Results: The IGF system has been linked to colorectal malignancy by a convergence of data from epidemiological, clinical and laboratory-based sources.

Conclusion: Further work is needed to characterise the IGF system expression in the colon. Such clarification could lead to the identification of targets that can be manipulated for clinical advantage.

PubMed Disclaimer

References

    1. Int J Cancer. 2003 Dec 20;107(6):873-7 - PubMed
    1. Carcinogenesis. 2003 Mar;24(3):393-401 - PubMed
    1. Cancer Res. 1996 Feb 1;56(3):523-6 - PubMed
    1. J Endocrinol. 2003 Dec;179(3):405-15 - PubMed
    1. J Clin Endocrinol Metab. 1995 Nov;80(11):3223-6 - PubMed

MeSH terms

LinkOut - more resources