Review
doi: 10.1016/j.cell.2005.06.002.
RNA interference libraries prove their worth in hunt for tumor suppressor genes
Affiliations
- PMID: 15960967
- DOI: 10.1016/j.cell.2005.06.002
Item in Clipboard
Review
RNA interference libraries prove their worth in hunt for tumor suppressor genes
Cell.
.
Free article
Abstract
RNA interference has been promoted as an ideal tool for functional genomics, but to date the success stories have principally been in model organisms. Two papers in this issue of Cell change all that: use of RNA interference libraries targeting large proportions of the human genome to uncover two novel tumor suppressor genes. REST is a transcriptional repressor that silences neuron-specific gene expression, and PITX1 is a homeodomain transcription factor that promotes the expression of a negative regulator of Ras.
Comment on
-
A genetic screen for candidate tumor suppressors identifies REST.Cell. 2005 Jun 17;121(6):837-48. doi: 10.1016/j.cell.2005.03.033. Cell. 2005. PMID: 15960972
-
A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity.Cell. 2005 Jun 17;121(6):849-58. doi: 10.1016/j.cell.2005.04.017. Cell. 2005. PMID: 15960973
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
