Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2005 Jun;365(9477):2122-4.
doi: 10.1016/S0140-6736(05)66735-9.

Blood vessels engineered from human cells

Melissa Poh  1 , Matthew Boyer, Amy Solan, Shannon L M Dahl, Dawn Pedrotty, Soma S R Banik, J Andrew McKee, Rebecca Y Klinger, Christopher M Counter, Laura E Niklason
Affiliations

Blood vessels engineered from human cells

Melissa Poh et al. Lancet. 2005 Jun.

Abstract

Tissue engineering has made considerable progress in the past decade, but advances have stopped short of clinical application for most tissues. We postulated that an obstacle in engineering human tissues is the limited replicative capacity of adult somatic cells. To test this hypothesis, the effectiveness of telomerase expression to extend cellular lifespan was assessed in a model of human vascular tissue engineering. Telomerase expression in vascular cells isolated from elderly patients enabled the successful culture of engineered autologous blood vessels. Engineered vessels may one day provide a source of bypass conduit for patients with atherosclerotic disease.

PubMed Disclaimer

Comment in

  • Telomerase expression in somatic cells.
    Brey EM, Greisler HP. Brey EM, et al. Lancet. 2005 Jun 18-24;365(9477):2068-9. doi: 10.1016/S0140-6736(05)66715-3. Lancet. 2005. PMID: 15964429 No abstract available.
  • Blood vessels engineered from human cells.
    Kassem M, Burns J, Abd-Allah B. Kassem M, et al. Lancet. 2005 Sep 10-16;366(9489):891-2; author reply 892-3. doi: 10.1016/S0140-6736(05)67311-4. Lancet. 2005. PMID: 16154007 No abstract available.
  • Blood vessels engineered from human cells.
    Torensma R. Torensma R. Lancet. 2005 Sep 10-16;366(9489):892; author reply 892-3. doi: 10.1016/S0140-6736(05)67312-6. Lancet. 2005. PMID: 16154009 No abstract available.

Publication types

LinkOut - more resources