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Review
. 2005 Jul;25(13):5307-16.
doi: 10.1128/MCB.25.13.5307-5316.2005.

A subset of nuclear receptor coregulators act as coupling proteins during synthesis and maturation of RNA transcripts

Didier Auboeuf  1 , Dennis H Dowhan, Martin Dutertre, Natalia Martin, Susan M Berget, Bert W O'Malley
Affiliations
Review

A subset of nuclear receptor coregulators act as coupling proteins during synthesis and maturation of RNA transcripts

Didier Auboeuf et al. Mol Cell Biol. 2005 Jul.
No abstract available

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Figures

FIG. 1.
FIG. 1.
Gene expression is a multistep process, and each step is made by the sequential recruitment of small preformed complexes performing successive reactions. Transcription factors like NRs recognize response elements within target promoters and recruit transcriptional coregulators that exist in preformed small complexes (Co. Complex). The sequential recruitment of different sets of coregulators leads to the formation of the transcriptosome, which ultimately allows the RNA pol II (PII) to be fully processive. After the synthesis of 20 to 40 nt, the 5′ end of the transcript is methylated (cap) through the sequential action of three enzymes. This cap structure plays a role in stability and translation of the mRNA. Similarly, after recognition of sequences at the 3′ end of the gene, transcription stops (T, termination) and the transcript is cleaved upstream of the termination site. The 3′ end is modified by the addition of a polyadenylated tail (pA) that also plays a role in the stability and translation of the mRNA. This step is made by the sequential recruitment of small preformed complexes. As soon as the primary transcript emerges from the RNA pol II CTD, splicing regulatory sequences within exons or introns are recognized by SFs that recruit preformed small complexes (U snRNPs) on the pre-mRNA, which leads to the formation of the spliceosome. The splicing process is in turn coupled to the export of the mRNA translated in the cytosol.
FIG. 2.
FIG. 2.
Transcriptional coregulators present within the spliceosome. SFs recognize exonic or intronic splicing regulatory sequences and help the recognition of neighboring splice sites (5′ SS and 3′ SS) by recruiting the spliceosome subcomplexes or snRNPs (U1, U2, U4, U5, and U6). Several proteins (shown within grey circles) that form part of the spliceosome are also transcriptional coregulators, which suggests that they could be recruited through the transcriptional machinery.
See this image and copyright information in PMC

References

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