[The nephrotoxic effects of single duck immunoglobulins in the triggering of Masugi nephritis]

Abstract

Studies were conducted into the roles played by various duck immunoglobulins in the anti-basal membrane of nephrotoxic nephritis in rabbit. The 7.8S and 5.7S immunoglobulins which originated from nephrotoxic duck serum were found to be responsible for the development of nephritis in rabbit. No pathogenetic role was played by any other proteins of duck serum. The affinity for the glomerulus basal membrane of 7.8S immunoglobulin was found to be higher than that of 5.7S globulin. As to trigger dosage, nephritis was safely inducted by 10 mg/kg body weight (BW) in the context of 7.8S immunoglobulins and by 15 mg/kg BW in the case of 5.7S immunoglobulins. One and the same morphological nature was recorded from nephritis, no matter by which of the above immunoglobulins it had been caused. Nephrotoxic duck immunoglobulins proved to be highly suitable for induction of experimental glomerulonephritis due to absence from this model of the heterologous phase of nephritis. Hence, the autologous phase is unambiguous and can be examined with higher accuracy.