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. 1992 May 8;1125(3):274-9.
doi: 10.1016/0005-2760(92)90056-2.

Characteristics and subcellular localization of pristanoyl-CoA synthetase in rat liver

R J Wanders  1 , S Denis, C W van Roermund, C Jakobs, H J ten Brink
Affiliations

Characteristics and subcellular localization of pristanoyl-CoA synthetase in rat liver

R J Wanders et al. Biochim Biophys Acta. .

Abstract

We have investigated the activation of pristanic acid to its CoA-ester in rat liver. The results show that peroxisomes, mitochondria as well as microsomes contain pristanoyl-CoA synthetase activity. On the basis of competition experiments and immunoprecipitation studies using antibodies raised against rat liver microsomal long-chain fatty acyl-CoA synthetase (EC 6.2.1.3) we conclude that pristanic acid is activated by the same enzyme which activates long-chain fatty acids, i.e., long-chain fatty acyl-CoA synthetase.

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