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Case Reports
. 2005 Jul;89(7):925-6.
doi: 10.1136/bjo.2004.055400.

Morquio syndrome: electron microscopic findings

T Leslie, M A R Siddiqui, D A Aitken, C M Kirkness, W R Lee, A I Fern
Case Reports

Morquio syndrome: electron microscopic findings

T Leslie et al. Br J Ophthalmol. 2005 Jul.
No abstract available

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Figures

Figure 1
Figure 1
(A) Within the cytoplasm an irregular electron dense mass (arrowhead) is surrounded by concentric membranes (arrow). A granular deposit is present in the stroma around the cell membrane (*) (×120 000). (B) Normal keratocytes were absent from the stroma—the cytoplasm of each cell contained inclusions although the content was variable. Some cells were disrupted by the volume of the inclusions (arrow): many of the cells were surrounded by a layer of electron dense granular material (arrowheads). The corneal lamellae were distorted by the swollen cells (×3800).
Figure 2
Figure 2
(A) In some sectors Bowman’s layer was absent and the epithelium was in contact with fibrous tissue over a thick basement membrane (arrow). Intracytoplasmic bodies were absent from the fibroblasts within the fibrous tissue (arrowheads) (×3800). (B) At lower magnification the inclusions appear to be amorphous in parts, but this represents the concentric lamellar material. The lamellae contain spindle-shaped strips of wide banded collagen (arrowhead). The cell with preserved cytoplasm containing inclusions is surrounded by a layer of electron dense granular material (arrows) (×9600). (C) Descemet’s membrane is of normal thickness. The endothelium contains membranous inclusions, which accumulate to such a level that the cells are cystic (arrow) (×4500). (D) When examined by scanning electron microscopy, the posterior endothelial surface is nodular as a result of the accumulation of intracytoplasmic inclusions. Linear areas of cell disruption are present (×850).
See this image and copyright information in PMC

References

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