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Clinical Trial
. 2005 Jul;76(7):992-5.
doi: 10.1136/jnnp.2004.043273.

Tourette's syndrome and deep brain stimulation

J L Houeto  1 , C Karachi, L Mallet, B Pillon, J Yelnik, V Mesnage, M L Welter, S Navarro, A Pelissolo, P Damier, B Pidoux, D Dormont, P Cornu, Y Agid
Affiliations
Clinical Trial

Tourette's syndrome and deep brain stimulation

J L Houeto et al. J Neurol Neurosurg Psychiatry. 2005 Jul.

Abstract

In this prospective double blind randomised "N of 1" study, a patient with a severe form of Tourette's syndrome was treated with bilateral high frequency stimulation of the centromedian-parafascicular complex (Ce-Pf) of the thalamus, the internal part of the globus pallidus (GPi), or both. Stimulation of either target improved tic severity by 70%, markedly ameliorated coprolalia, and eliminated self injuries. Severe forms of Tourette's syndrome may benefit from stimulation of neuronal circuits within the basal ganglia, thus confirming the role of the dysfunction of limbic striato-pallido-thalamo-cortical systems in this disorder.

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  • Surgery for movement disorders: new applications?
    Limousin-Dowsey P, Tisch S. Limousin-Dowsey P, et al. J Neurol Neurosurg Psychiatry. 2005 Jul;76(7):904. doi: 10.1136/jnnp.2004.062117. J Neurol Neurosurg Psychiatry. 2005. PMID: 15965193 Free PMC article. No abstract available.

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