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Review
. 2005 Feb;38(1):79-83.
doi: 10.1080/08916930400022681.

Anti-Mi-2 antibodies

Anna Ghirardello  1 , Sandra Zampieri, Luca Iaccarino, Elena Tarricone, Raffaele Bendo, Pier Franca Gambari, Andrea Doria
Affiliations
Free article
Review

Anti-Mi-2 antibodies

Anna Ghirardello et al. Autoimmunity. 2005 Feb.
Free article

Abstract

Autoantibodies targeting the Mi-2 nuclear antigen represent one of the serologic hallmarks of idiopathic inflammatory myopathies, with a diagnostic sensitivity and specificity of approximately 4-18% and 98-100%, respectively. Mi-2 antigen is a component of the nuclesome remodeling-deacetylase (NuRD) complex involved in transcription regulation.Anti-Mi-2 antibodies are strongly associated with dermatomyositis (frequency up to 31%) and have a very high positive predictive value for such disease subset. A strong correlation with HLA-DR7 has been demonstrated. At the moment, optimal serologic testing is achieved by ELISA screening on recombinant Mi-2 antigen and confirmation of positive results on immunoblot.

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