[Effects of landiolol on cardiovascular responses, bispectral index and body movement during endotracheal intubation]

Abstract

Background: We investigated the effects of a novel highly cardioselective short-acting beta-blocker, landiolol, on cardiovascular response, bispectral index and body movement during endotracheal

Methods: Forty ASA class 1 patients were randomly allocated into 2 groups, in a double-blind fashion; 1) 20 patients received landiolol 125 microg x kg(-1) x min(-1) for one minute followed by 40 microg x kg(-1) x min(-1) (landiolol group), and 2) 20 patients received saline (control group). Landiolol or saline was started 6 min after a target controlled infusion of propofol (effect-site concentration 4 microg x ml(-1)). The trachea was intubated 11 min after propofol infusion. Heart rate, mean arterial pressure, and bispectral index were recorded. In addition, the "isolated forearm" technique was used to detect body movement during endotracheal intubation.

Results: Maximum changes in heart rate (control; 48% versus landiolol; 19%), mean arterial pressure (51% versus 39%), and bispectral index (31% versus 12%) observed during endotracheal intubation were significantly less in the landiolol group. More patients in the control than in the landiolol group moved after endotracheal intubation (19 versus 11, P<0.05).

Conclusions: Our results suggest that landiolol infusion was effective to attenuate the hemodynamic, arousal and somatic responses to endotracheal intubation.