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Comparative Study
. 2005 Jun 20;201(12):1869-73.
doi: 10.1084/jem.20050584.

No audible wheezing: nuggets and conundrums from mouse asthma models

Joshua A Boyce  1 , K Frank Austen
Affiliations
Comparative Study

No audible wheezing: nuggets and conundrums from mouse asthma models

Joshua A Boyce et al. J Exp Med. .

Abstract

Mouse models of T helper type 2 (Th2) cell-biased pulmonary inflammation have elucidated mechanisms of sensitization, cell traffic, and induced airway hyperresponsiveness (AHR). Nonetheless, most mice lack intrinsic AHR, a central property of human asthma, and disparities persist regarding the contributions of eosinophils and mast cells and the sensitivity to induced AHR in the commonly used mouse strains. We suggest that these discordances, reflecting methodological and genetic differences, may be informative for understanding heterogeneity of human asthma.

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