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Review
. 2005 May 8;146(19):947-52.

[The role of drug metabolizing enzymes in the effect and side-effect of the drugs]

[Article in Hungarian]
László Vereczkey  1 , Katalin Jemnitz, Katalin Monostory, Zsuzsa Veres, László Kóbori
Affiliations
  • PMID: 15969306
Review

[The role of drug metabolizing enzymes in the effect and side-effect of the drugs]

[Article in Hungarian]
László Vereczkey et al. Orv Hetil. .

Abstract

The authors give an overview on the role of drug metabolizing enzymes in the effect and side-effect of drugs. They describe the properties of cytochrome P450 and other phase I enzymes (hydrolases, flavin-monooxygenases), as well as of phase II. enzymes (glucuronyl-, sulfate-, glutathione-, acetyl-, methyltranferases), their polymorphism, inductive and inhibition properties. The possible drug-drug interactions are discussed in detail.

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