[Adenylate cyclase. A possible factor in the pathogenicity of Yersinia pestis]
[Article in
French]
Affiliations
- PMID: 1596952
Item in Clipboard
[Adenylate cyclase. A possible factor in the pathogenicity of Yersinia pestis]
[Article in
French]
Bull Soc Pathol Exot.
1992.
Abstract
Biological effect of homogenous preparation of Y. pestis adenylate cyclase on eucaryotic cells was studied. Adenylate cyclase, added (7.5 x 10(8) g/ml) to guinea pig macrophages lowers the level of chemiluminescence to 50-70%, has an appreciable cytotoxic effect on peritoneal macrophages and suppresses phosphorylation processes of leucocyte proteins from white mice. The experimental results obtained allow to suggest Y. pestis adenylate cyclase to be a pathogenic factor, contributing to the development of plague infection.
Similar articles
-
[Role of histamine receptors of mouse and guinea pig peritoneal leukocytes in the pathogenetic effect of Yersinia pestis adenylate cyclase].Biull Eksp Biol Med. 1992 Jun;113(6):629-31. Biull Eksp Biol Med. 1992. PMID: 1446035 Russian.
-
[Evaluation of the modulating action of Yersinia pestis adenylate cyclase on guinea pig peritoneal leukocytes using chemiluminescence].Zh Mikrobiol Epidemiol Immunobiol. 1987 Jul;(7):59-63. Zh Mikrobiol Epidemiol Immunobiol. 1987. PMID: 2823508 Russian.
-
[The participation of the adrenergic receptors of the peritoneal leukocytes from white mice in the mechanism of the cellular control of the action of Yersinia pestis adenylate cyclase].Zh Mikrobiol Epidemiol Immunobiol. 1989 Oct;(10):6-10. Zh Mikrobiol Epidemiol Immunobiol. 1989. PMID: 2609813 Russian.
-
[The protective activity of the adhesion pili of Yersinia pestis].Zh Mikrobiol Epidemiol Immunobiol. 1995 Sep-Oct;(5):26-9. Zh Mikrobiol Epidemiol Immunobiol. 1995. PMID: 8525726 Russian.
-
[Effect of anthrax toxin on the chemiluminescence of human leukocytes].Nauchnye Doki Vyss Shkoly Biol Nauki. 1988;(11):16-20. Nauchnye Doki Vyss Shkoly Biol Nauki. 1988. PMID: 3146991 Russian.
Cited by
-
Physiological calcium concentrations regulate calmodulin binding and catalysis of adenylyl cyclase exotoxins.EMBO J. 2002 Dec 16;21(24):6721-32. doi: 10.1093/emboj/cdf681. EMBO J. 2002. PMID: 12485993 Free PMC article.
-
RAB11-mediated trafficking in host-pathogen interactions.Nat Rev Microbiol. 2014 Sep;12(9):624-34. doi: 10.1038/nrmicro3325. Nat Rev Microbiol. 2014. PMID: 25118884 Free PMC article. Review.