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Review
. 2005 Oct;451(1):72-80.
doi: 10.1007/s00424-005-1460-0. Epub 2005 Jun 22.

The diacylgylcerol-sensitive TRPC3/6/7 subfamily of cation channels: functional characterization and physiological relevance

Alexander Dietrich  1 , Hermann Kalwa, Benjamin R Rost, Thomas Gudermann
Affiliations
Review

The diacylgylcerol-sensitive TRPC3/6/7 subfamily of cation channels: functional characterization and physiological relevance

Alexander Dietrich et al. Pflugers Arch. 2005 Oct.

Abstract

Among the "classical" or "canonical" transient receptor potential (TRPC) family, the TRPC3, -6, and -7 channels share 75% amino acid identity and are gated by exposure to diacylglycerol. TRPC3, TRPC6, and TRPC7 interact physically and coassemble to form functional tetrameric channels. This review focuses on the TRPC3/6/7 subfamily and describes their functional properties and regulation as homomers obtained from overexpression studies in cell lines. It also summarizes their heteromultimerization potential in vitro and in vivo and presents initial data concerning their physiological functions analyzed in isolated tissues with downregulated channel activity and gene-deficient mouse models.

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References

    1. Nat Cell Biol. 2004 Feb;6(2):113-20 - PubMed
    1. Cell Calcium. 2002 Oct;32(4):201-7 - PubMed
    1. Sci STKE. 2004 Jul 20;2004(243):pe35 - PubMed
    1. J Biol Chem. 1998 Jan 2;273(1):133-42 - PubMed
    1. J Biol Chem. 2003 Jul 11;278(28):25758-65 - PubMed

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