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Review
. 2005 Jun;5(6):523-43.
doi: 10.2174/1389557054023251.

Allosterism at muscarinic receptors: ligands and mechanisms

N J M Birdsall  1 , S Lazareno
Affiliations
Review

Allosterism at muscarinic receptors: ligands and mechanisms

N J M Birdsall et al. Mini Rev Med Chem. 2005 Jun.

Abstract

The evaluation of allosteric ligands at muscarinic receptors is discussed in terms of the ability of the experimental data to be interpreted by the allosteric ternary complex model. The compilation of useful SAR information of allosteric ligands is not simple, especially for muscarinic receptors, where there are multiple allosteric sites and complex interactions.

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