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. 2005 Jun 24:6:34.
doi: 10.1186/1471-2474-6-34.

Bone mineral density, body mass index and cigarette smoking among Iranian women: implications for prevention

Azam Baheiraei  1 , Nicholas A Pocock, John A Eisman, Nguyen D Nguyen, Tuan V Nguyen
Affiliations

Bone mineral density, body mass index and cigarette smoking among Iranian women: implications for prevention

Azam Baheiraei et al. BMC Musculoskelet Disord. .

Abstract

Background: While risk factors of osteoporosis in Western populations have been extensively documented, such a profile has not been well studied in Caucasians of non-European origin. This study was designed to estimate the modifiable distribution and determinants of bone mineral density (BMD) among Iranian women in Australia.

Methods: Ninety women aged 35 years and older completed a questionnaire on socio-demographic and lifestyle factors. BMD was measured at the lumbar spine (LS) and femoral neck (FN) using DXA (GE Lunar, WI, USA), and was expressed in g/cm2 as well as T-score.

Results: In multiple regression analysis, advancing age, lower body mass index (BMI), and smoking were independently associated with LS and FN BMD, with the 3 factors collectively accounting for 30% and 38% variance of LS and FN BMD, respectively. LS and FN BMD in smokers was 8% lower than that in non-smokers. Further analysis of interaction between BMI and smoking revealed that the effect of smoking was only observed in the obese group (p = 0.029 for LSBMD and p = 0.007 for FNBMD), but not in the overweight and normal groups. Using T-scores from two bone sites the prevalence of osteoporosis (T-scores <or= -2.5) was 3.8% and 26.3% in pre-and post-menopausal women, respectively. Among current smokers, the prevalence was higher (31.3%) than that among ex-smokers (28.6%) and non-smokers (7.5%).

Conclusion: These data, for the first time, indicate that apart from advancing age and lower body mass index, cigarette smoking is an important modifiable determinant of bone mineral density in these Caucasians of non-European origin.

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Figures

Figure 1
Figure 1
Mean and standard error of lumbar spine (upper panel) and femoral neck (lower panel) bone mineral density (g/cm2) by smoking status.
Figure 2
Figure 2
Mean and standard error of lumbar spine (upper panel) and femoral neck (lower panel) bone mineral density (g/cm2) by body mass index and smoking status.
Figure 3
Figure 3
Interaction between age and smoking status on lumbar spine (upper panel) and femoral neck (lower panel) bone mineral density (g/cm2).
See this image and copyright information in PMC

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