Comment
doi: 10.1016/j.chembiol.2005.06.005.
Off the shelf but not mass produced
Affiliations
- PMID: 15975506
- DOI: 10.1016/j.chembiol.2005.06.005
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Comment
Off the shelf but not mass produced
Chem Biol.
2005 Jun.
Abstract
Using high-throughput screening, Jo et al. in this issue of Chemistry & Biology [1] have identified SEW2871 as a structurally unique sphingosine 1-phosphate(1) (S1P(1)) receptor agonist. SEW2871 binds to and activates the S1P(1) receptor and initiates a survival signaling pathway similar to that of S1P.
Comment on
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S1P1-selective in vivo-active agonists from high-throughput screening: off-the-shelf chemical probes of receptor interactions, signaling, and fate.Chem Biol. 2005 Jun;12(6):703-15. doi: 10.1016/j.chembiol.2005.04.019. Chem Biol. 2005. PMID: 15975516
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